Home — Health Study: Chinese COVID shot may offer elderly poor protection

Study: Chinese COVID shot may offer elderly poor protection

by Mary Sewell

BUDAPEST, Hungary — A new study suggests that a Sinopharm vaccine offers poor protection from COVID-19 among older people, raising questions for dozens of countries that have given the Chinese company’s shots to their most vulnerable populations. A survey of blood samples from 450 people in Hungary at least two weeks after their second Sinopharm dose found that 90% under 50 developed protective antibodies. But the percentage declined with age, and 50% of those over 80 had none.

The study by two Hungarian researchers was posted online this week but has not yet been reviewed by other scientists. Three outside experts said they had no problems with the methodology of studying the vaccine developed by Sinopharm’s Beijing Institute of Biological Products. This is very, very worrying that these high-risk people have a poor antibody response,” said Jin Dong-yan, a Hong Kong University virologist who was not affiliated with the study.

Antibody levels are not a direct measure of how protected a person is from COVID-19, but there is growing evidence that they are a good proxy. One expert cautioned that the choice of test kits could have limited the accuracy of the measurements. Still, the study’s findings have value and are the first public scientific attempt to analyze the effect of the Sinopharm vaccine on older people, said Wang Chenguang, a former professor at Peking Union Medical College and an immunology expert.

China’s National Health Commission declined to comment on the study, saying it would only respond to the studies of governments or major research institutions. This is not the first time questions have been raised about the vaccine’s efficacy, which was given the green light by the World Health Organization in May and is being used in more than 50 countries, many of which seized upon it when other vaccines were tough to come by. A spokesperson for the WHO said Wednesday that its experts “are aware of the study and continue to look at all available evidence.” The agency’s advisers raised questions about whether it protected people 60 and over months ago. Still, when it was OK’d, a WHO expert said there was no reason to think it would work differently in older people.

The vaccine is one of two similar shots developed by Sinopharm. The state-owned Chinese company’s research showed that almost all the participants in final-stage clinical trials were under 60 — and its researchers said there was insufficient evidence to say whether the vaccines work in older people. Overall, the Beijing Institute vaccine was found to be 78% effective. In Hungary, concern about the shots led many to seek private antibody tests.

After initially rebuffing calls for a government response to efficacy concerns — including from the antibody study’s authors Balazs Sarkadi and Tamas Ferenci — Prime Minster Viktor Orban finally acquiesced last week in the face of growing public anger. He announced that the government would give its citizens an optional third shot. Eventually, the capital city of Budapest offered free testing to elderly residents as part of a bid to ratchet up pressure on the government to conduct its own more comprehensive survey and provide booster shots to those who need them.

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